1983 A.J. Kemper et al.
"Hydrogen Peroxide Contrast Enhanced Two-Dimensional Echocardiography: Real Time In Vivo Deliniation of Regional Myocardial Perfusion"
A.J. Kemper, J.E. O'Boyle, S. Sharma, C.A. Cohen, R.A. Kloner, S.F. Khuri and A.F. Parisi
September, 1983
Volume 68 (3)
Pages 603-611
PMID: 6872171 [PuMed - indexed for MEDLINE]
A quote from the following paper...
"In this study we used a new echocardiographic contrast agent of dilute hydrogen peroxide and blood. The intense echocardiographic contrast engendered by the mixture of hydrogen peroxide and blood obviates the need for intracoronary contrast injection.  Supra-aortic injection allows the entire coronary circulation to be observed after one injection.  No important effect was seen on hemodynamics or cardiac irritability after as many as six injections of the dilute hydrogen peroxide and blood mixture.  The size and rate of formation of oxygen bubbles produced by hydrogen peroxide injection is dependent on the amount, dilution, and rate of the solution injected.  Hydrogen peroxide has been injected intravascularly with safety in man. Wang et al. have reported their experience with 100 patients, 21 of which had cyanotic congenital heart disease, after the intravenous injection of doses of hydrogen peroxide 1.5 to 5 times larger than those we used. Available data suggest that this technique may be applicable to studies of evolving myocardial infarction in man."
[Comment from author/webmaster James Paul Roguski: I find it interesting that "skeptics" claim that the injection of hydrogen peroxide is unproven and dangerous, yet it is used by cardiac imaging specialists to enhance their ability to observe the beating heart.  In this study, hydrogen peroxide was injected into the aorta so that the microbubbles of oxygen that it produces in the blood would purposefully enter into the tissue of the heart!  If that was done safely, and with benefit, why do they criticize intravenous infusions and/or drinking hydrogen peroxide?]



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